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sábado, 3 de março de 2012

NanoBusiness Interview Series – Andrew Maynard, Ph.D.


I have known Andrew Maynard for over 10 years. We have agreed and disagreed on various EHS issues concerning the Nanotechnology Community during our relationship. Even though we have disagreed from time to time I have always found his opinions valuable and thought provoking.
Andrew previously co-chaired the NNI’s Nanotechnology Health and Environment Implications group while working at the National Institute for Occupational Safety and Health. He then became Chief Science Advisor to the Woodrow Wilson Center’s Project on Emerging Nanotechnologies and a frequent spokesperson for PEN’s EHS concerns. He has served on numerous government advisory councils in the U.S. and Canada, including the panels that developed the National Academies report on nanoEHS in 2009 and the draft NRC EHS Research Strategy I discussed in last week’s newsletter.
Today’s interview was written by one of the original Nanotechnology writers, Howard Lovy. The other contributor for today’s interview is Phil Lippel, Ph.D., NanoBusiness Board Member. The opinions expressed by Andrew Maynard are his opinions and this interview is intended to continue our policy of providing all viewpoints in the Nanotechnology Community.
NanoBusiness Interview – Andrew Maynard, Ph.D.
When Andrew Maynard, director of the Risk Science Center at the University of Michigan, read the text of a recent lawsuit by consumer advocates against the U.S. Food and Drug Administration, which claims the FDA is failing to regulate nanomaterials in products, one phrase jumped out at him. The groups used the words “fundamentally unique properties” when referring to nanoscale ingredients.
The phrase, in fact, comes directly from marketing material of the National Nanotechnology Initiative. So, in one sense, the nanotech industry is a victim of its own public relations, Maynard believes. A phrase used to promote nanotech commercialization is being thrown back at nanotech advocates by those who would use the same logic to demand strict regulations.
“There is an assumption that you can have everything your own way,” Maynard says. “You can say something was unique and important and world-changing, selling the hype, and yet not really understanding what the long-term consequences of that hype are.”
This is what Maynard does for a living. He tries to reach beyond hype and beyond gloom to assess and communicate the real risks associated with emerging technologies, including nanotechnology. But he approaches these assessments from a starting point that seems increasingly difficult to achieve in these polarized political times – one based on scientific principles rather than political agenda.
The problem with that “unique properties” phrase that has been so misused over the years is that the science does not necessarily back it up. Material at the nanoscale is not necessarily any different from its macroscale cousin.
“Now, with the research that’s been generated in the last few years, it’s become increasingly clear that there’s no well-defined set of materials that raise red flags when it comes to size,” Maynard says. “About the best you can do is say that the smaller and more sophisticated you make things the more you have to think about a wide range of questions when you’re evaluating safety.”
So, when Maynard now discusses nanotechnology and potential risk, he’s not likely to even use the “n” word. He’s talking about advanced materials, or “sophisticated materials.”
For example, he says, what questions do you ask when trying to determine whether quantum dots are safe? Well, you talk about the composition of the quantum dot, how its physical and chemical structure determines how it interacts with biological systems, and how its size effects where it goes in the body and how it interacts within it.
But those are not nano-specific questions,” he says. “They’re the questions associated with a specifically designed material.”
The same thing with titanium dioxide found in sunscreens. Shrink them down to nanosize and you get concerns raised by advocacy groups such as the Friends of the Earth and others involved in the lawsuit against the FDA, but the research says titanium dioxide, even at that size, is still pretty benign.
It has taken Maynard a few years to reach this point in his thinking about nanotech. Many in the nanotech business community might remember Maynard when he was scientific adviser for the Wilson Center’s Project on Emerging Nanotechnologies (PEN) between 2005 and 2008. The PEN raised many questions about the potential risks of nanomaterials. Has he changed since his Wilson Center days?
“I have, which is I think inevitable. If you take a young field, our knowledge is going to change over time,” Maynard says. “And if we don’t change our opinions based on that knowledge there’s something wrong.”
But one thing that has not changed is his belief that if nanotech is going to develop into a sustainable industry that is economically robust, it needs to also be “socially robust” and develop with an eye toward social implications.
“It makes a lot of business sense, if you’re developing any new technology – not just nanotech or whatever – to be aware of the possiblities of what might go wrong with that technology and those products and shore things up as early as possible,” he says.
The problem, though, is that roughly 10 years after these questions were first asked, after the U.S. government has invested millions in looking at the environmental and health implications of nanotechnology, we still are not much wiser.
“We know a lot more now,” Maynard says. “The question is do we know a lot more that’s useful now. That’s what I would debate.” The problem, he says, is that the wrong questions are being asked.
Take, for example, carbon nanotubes. There is an assumption by many researchers, Maynard said, that the material is similar to asbestos. But nanotubes are not straight, long, rigid fibers, yet this assumption is driving the research.
I am quite often concerned that you talk to toxicology groups doing research on carbon nanotubes, I don’t think many of them could actually accurately describe to you the physical form or nature of a carbon nanotube. And yet they’re doing research under various assumptions of what these things are like.”
So, this is the mission of Maynard’s Risk Science Center – to start discussions about the risks of technology with a grounding in real science and not on speculation, taking and “evidence-based approach.”
He’s come a long way since the early 1990s, Maynard, now 46, worked on his Ph. D. at Cambridge in the UK, using advanced microscopy techniques to analyze airborne particles. At the time, many of his colleagues told him he was wasting his time. There would be no future in tiny materials. They were wrong, of course, and Maynard got involved further and further into studying emerging technologies. Eventually, he made the jump from doing science to studying the proper ways of communicating it to the public.
Next on his agenda is looking at issues involved in advanced manufacturing, which overlaps with nanotech. Again, he said he is asking questions having to do with how businesses using new manufacturing technologies, producing new materials, can predict where economic and social barriers are going to be and have a plan to get over them. That includes codes of conduct, standards and best practices. It is up to the industry, itself, to make sure these are in place. The alternative is unwanted regulation.
The most-important advice Maynard gives to the nanotech business community is to simply be aware of the possible implications of the technology they’re developing and make sure regulatory agencies are properly informed of what is being done. But there is no need to respond to individual challenges such as this lawsuit against the FDA.
“It’s worthwhile playing the long game and not being too reactionary to what happens,” Maynard says. “What’s happened over the last 10 years is that concerns over nanotechnology really haven’t gained that much traction.”
In fact, it’s just the opposite. People, in general, remain excited about the prospects of nanotechnology.
I think the bottom line is to be as honest as possible, and talk to people,” Maynard says. “One of the biggest problems is if you come across as trying to hide things or trying to obscure things. Generally, people are really excited about this technology. They just want to know what’s going on. They want to know what it’s about.”
I hope you have enjoyed this interview. We look forward to continuing our EHS discussions at the Nanotech Commercialization Conference http://www.nanoevent.org/ April 4-5 in Research Triangle – Durham, NC.
Regards,
Vincent Caprio “Serving the Nanotechnology Community for Over a Decade”
Executive Director
NanoBusiness Commercialization Association
203-733-1949
vincent@nanobca.org
www.nanobca.org
www.vincentcaprio.org

sexta-feira, 2 de março de 2012

ECHA Announces Plans to Update Guidance for Registration of Nanoform Substances


On February 22, 2012, the European Chemicals Agency (ECHA) issued a press release announcing that it is currently preparing an update of its Guidance on Information Requirements and Chemical Safety Assessment (IR & CSA) based on the European Commission’s Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) Implementation Project on Nanomaterials (RIP-oN). 


Because the next registration deadline of May 31, 2013, is approaching quickly, ECHA “will facilitate compliance of all potential registrants well in advance.” ECHA intends to update the Guidance on IR & CSA later in 2012, in line with the outcomes of RIP-oNs 2 and 3. 

ECHA states that registrants may already find it useful to refer to the RIP-oN reports when preparing registration dossiers covering nanomaterials. 

ECHA reminds registrants, however, “to ensure that safe use of their substance should be demonstrated in the registration dossier, and hence that the data of the submitted properties as well as related risk assessment and management information should be applicable and appropriate for the nanoforms covered by the registration.”

According to ECHA, the RIP-oN 1 report on the substance identification of nanomaterials also contains useful information that can be integrated into the IUCLID 5 manuals. Because the experience in addressing characterization of nanoforms is still developing, ECHA states it will not revise the current guidance on substance identity. Furthermore, ECHA notes, “for other areas it is clear that further scientific development and research are still necessary before providing definitive guidance updates.”



Fonte: Nanotech.Lawbc

Free webinar: Introduction to Nanomedicine


Radiological Technologies University would like to present Dr. Renat Letfullin as he hosts his "Introduction to Nanomedicine" webinar. The webinar will be hosted at 8 different dates/times.
The goal for this webinar is to build awareness about the revolutionary possibilities that nanotechnology holds for the field of medicine. He will describe the field, discuss possible applications for nanotechnology in medicine, and career opportunities.

Dr. Letfullin comes to us on sabbatical from Russia. He brings with him an arsenal of research, knowledge, and desire to find a cure for cancer through the use and implementation of nanomedicine. Dr. Letfullin has published multiple publications and books, the most recent being a chapter in the Springer Handbook of Nanotechnology and Plasmonic Nanomaterials for Nanomedicine Computational Studies of New Materials II.
The potential of nanotechnology is revolutionary. "Nanotechnology job projections are estimated to be nearly two million workers worldwide by 2015"-National Nanotechnology Initiative. RTU has the nation's first MS in Nanomedicine and MS with a dual focus in Nanomedicine and Medical Physics. RTU hopes to build the bridge to narrow the gap between nanotechnology and medicine. For more information, visit www.rtuvt.com.
Dr. Renat Letfullin will be hosting the following webinars, each approximately 45-60 minutes. Please select one time most convenient for you and fill out the registration to attend the webinar. Don't forget to mark it on your calendar! The listed times are all EST.


Fonte: NanoWerk

Nanotechnology Research around the world: Chile


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The Centre for advanced interdisciplinary research in materials at the Faculty of Physical Sciences and Mathematics of Univertiy of Chile.
CIMAT activities provide a foundation of R & D on materials for a sustainable national development. The parameters that frame the Center’s activities include maintaining and expanding the markets of Copper and Molybdenum, the behavior of materials in the mining process, the development of new materials for the packaging industry exports and resolution of energy issues, environment and health.
Raul Quijada and Alejandro Toro directed the research department Catalytic and Polymeric Materials. This research field is focused on the development of materials with catalytic properties and their application in processes involving polymers production, environmental decontamination and production of renewable energy. Two of its research are:
  1. Synthesis and Application of nanostructured inorganic materials.
    Materials with porous nanostructures have special properties for their use as heterogeneous catalysts and in separation processes.
    Using sol-gel, self-assembly and hydrothermal synthesis techniques, materials such as zirconium oxide, ordered mesoporous silicas, zeolites, and laminar materials are prepared, among others.
  2. Preparation of new polymeric materials and nanocomposites.
The incorporation of inorganic particles with nanometric dimensions into polymeric matrix allows generating compound polymeric materials (nanocomposites) with improved properties or different ones from those of the starting polymer. Laminar clays are organically modified and combined with the polymer in molten state or through in-situ polymerization. For the purpose of improving the chemical affinity between the inorganic material and the polymer, compatibilizers have been developed based on the grafting of itaconic acid in the polymeric chain. This procedure allows the preparation of polypropylene (PP) nanocomposites with clay particles more exfoliated and improved mechanical properties.
Their other main research lines are Study and Development of catalysts for polymerization, Development and evaluation of polymeric, inorganic and composite separation membranes, Production and Purification of Fuel, Applications in atmospheric decontamination and Theoretical Researches.
More information:
Raúl Quijada y Alejandro Toro- Labbé
Centre for advanced interdisciplinary research in materials
Faculty of Physical Sciences and Mathematics
University of Chile http://www.uchile.cl/

Fonte:
Nanobugle

Nanotechnology Research around the world: Jordan


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The Material Science & Nanotechnology Laboratories at the University of Jordan
The material science and nanotechnology laboratories at Hamdi Mango Center for Scientific Research (HMCSR) incubate research in select projects that have the potential to be applied in Jordanian industry.
The material science and nanotechnology laboratories are divided into three research groups:
(I) The Superconductor Material Research Group: its goal is to produce superconductors from nano sized precursors via the coprecipitation method
(II) The Colloid and Surface Chemistry Research Group: its goals are to study colloidal solutions stability and to use phase science to study associated structure of amphiphilic systems.
(III) The Natural Geomaterials for Construction and Industrial Applications Research Group: its goals are to investigate the Jordanian zeolitic tuff and the mineralogical, chemical characterization and the adsorption capability towards organic and inorganic pollutants,
The laboratories include more than ten researchers coordinated by Prof. Hani N. Khoury. Main research projects currently ongoing are:
• The Effect of Nano-sized Starting Powers on the Physio-chemical Properties of the RE123 Superconducting Ceramics prepared Via Co precipitation method.
Characterization and benefits of the newly explored Jordanian zeolitic tuff from selected localities in northern, central, and southern Jordan and research into their capability for removing pollutants from water.
• Targeted-delivery of macromolecular drugs (Aptamers) to cancer cells
More information:
Prof. Hani N. Khoury khouryhn@ju.edu.jo
The University of Jordan
Amman 11942
Jordan 
www.ju.edu.jo/home.aspx 


Fonte: 
Nanobugle

Researchers consider environmental transformations of silver nanoparticles


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Scientists have published a critical review of current evidence concerning the environmental transformations of silver nanoparticles, and the impact of such transformations on toxicity.
The review highlights that silver nanoparticles readily transform in the aquatic environment, in particular when the silver particles react with other molecules such as sulphur. The researchers describe how such reactions can alter the physical and chemical stability of the nanoparticles, which in turn affects toxicity.
The authors also identify areas in which research is needed to improve predictions of the environmental impact of silver nanoparticles, which encompasses fundamental molecular-level studies, simplified model systems and experiments under realistic environmental conditions. 
They also highlight the need for toxicology studies of the chemical products formed following transformation of silver nanoparticles, and for characterisation of the physical properties of the substance to improve solubility and reactivity predictions.
The review is published in Environmental Science and Technology.

Are you concerned about the potential health impact of nanoparticles in our food and drugs?


Unscientific poll


Yes, recent studies point to a worrying health impact
42% (88 votes)
No, I'm not worried about it
20% (43 votes)
Maybe, but it's difficult to avoid consuming them even if I wanted to
38% (81 votes)
Total votes: 212
nanoparticles health

Questions raised over nanoparticle impact

Monday, 13 February 2012
Tests involving chickens have raised questions about the impact on health from engineered nanoparticles, the ultra-fine grains commonly used in drugs and processed foods.

Nano discs pose potential health risk


A revolutionary material that is used in computer technology could pose health risks to those involved in its manufacture.


Ultra-thin layers of carbon called graphene - heralded for its superconductive properties - could be harmful to the lungs when produced in a particular form.
Nanoplatelet use
The flexibility of these disc-shaped particles - known as nanoplatelets - mean they can be readily incorporated into plastic and rubber.
This gives these materials new and useful properties.
The nanoplatelets can also be used to enhance the electronic properties of touch screens.
Nanoplatelets are less than one carbon atom thick and invisible to the naked eye.
Aerodynamic action
Scientists studying nanoplatelets found they behaved like tiny Frisbees, and stay airborne.
Their aerodynamic properties mean that when inhaled the nanoplatelets can find their way deeper into the lungs compared with other forms of graphene.
The particles could accumulate in the lungs and cause damage.
Impact on manufacturing industry
This could potentially affect the health of people involved in manufacturing and handling graphene-based nanoplatelets.
The study, which looked at the aerodynamic and toxic properties of graphene-based nanoplatelets, was published in the journal ACS Nano ("Graphene-Based Nanoplatelets: A New Risk to the Respiratory System as a Consequence of Their Unusual Aerodynamic Properties").
We need to further assess the potential hazards posed by nanoplatelets made of graphene and other other materials, so that appropriate health and safety measures can be put in place for those involved in their manufacture.
Professor Ken Donaldson
Chair of Respiratory Toxicology

Fonte: The University of Edinburgh    

Flesh-eating Bacteria Inspire Superglue



A bio-inspired superglue has been developed by Oxford University researchers that can’t be matched for sticking molecules together and not letting go. It could prove to be a very useful addition to any toolbox for biotechnology or nanotechnology. You could use the glue to grab hold of proteins or stick them immovably to surfaces. You could even use it to assemble proteins and enzymes to build new structures on the nanometer scale.

"We’re very interested in creating protein assemblies.
We want to be able to treat proteins like Lego," explains Dr. Mark Howarth, who with his graduate student Bijan Zakeri at the Department of Biochemistry developed the superglue. "But previously we’ve been limited to ill-controlled processes or have had to build using weak biological interactions."


The Oxford biochemists came up with their new super-strength molecular glue by engineering an unusual protein from a type of bacteria that can cause life-threatening disease.

While many people carry 
Streptococcus pyogenes in their throat without any problems, the bacteria can cause infections. Some are mild, like impetigo in infants or a sore throat, but some can kill, like toxic shock syndrome or flesh-eating disease.
What attracted the biochemists’ interest was a specific protein that the bacteria use to bind and invade human cells.

"The protein is special because it naturally reacts with itself and forms a lock," says Howarth.
All proteins consist of amino acids linked together into long chains by strong covalent bonds. The long chains are folded and looped up into three-dimensional structures held together by weaker links and associations.
The protein FbaB from S. pyogenes has a 3-D structure that is stabilized by another covalent bond. This strong chemical bond forms in an instant and binds the loops of the amino acid chain together with exceptional strength.

Howarth and his colleagues reckoned, with a bit of engineering, they could split the protein around this extra covalent bond. Then, when the two parts were brought together again, they might dock and form this strong bond once more.

The two parts would be locked together immovably — stapling together anything else attached to their tails. That is what the researchers have demonstrated in this week’s PNAS.
They’ve nicknamed the larger fragment that formed the bulk of the original protein ‘SpyCatcher.’ Once SpyCatcher gets hold of the shorter protein segment, ‘SpyTag,’ it never lets go.

At least, the researchers with their collaborators at the University of Miami tried to measure the force needed to pull apart SpyTag from SpyCatcher using an atomic force microscope.
But, when they pulled on each end, the chemical links holding the proteins to the apparatus broke first. Boiling in detergent won’t separate the protein fragments either.

"Our system forms rapid covalent bonds with high efficiency and high stability," says Howarth.
When SpyCatcher and SpyTag are brought together, they bond in minutes with high yield. It doesn’t matter whether it is in acidic or neutral conditions, or whether it is 4°C or 37°C.
They will stick together in test tube reactions or inside cells. And, importantly, they don’t stick to other things — there’s no equivalent of getting your fingers stuck to the Airfix model you’re building.

Howarth explains that there isn’t really any equivalent way to bind biomolecules together. There are chemical reactions that can join two proteins together covalently, but often only small proportions react, they take a long time, or they require UV light, toxic catalysts or reaction conditions that could damage living cells.

The ability to attach SpyCatcher and SpyTag onto other molecules you want to glue together could have many applications. For example, sticking all the enzymes involved in a chemical process into a small factory could speed reactions and increase yields.

Or, you might want to bring all the elements together that plants use to turn sunlight into energy with only water as a waste product. Scientists have long wanted to come up with ways of achieving photosynthesis artificially for useable green energy.
However, the first uses of the molecular superglue may well be in the research lab, grabbing hold of structures within biological cells. That way, you could resist the forces generated by important motors, machines and transporters inside the cell.

Howarth and his team are now working on developing the molecular superglue technology through Isis Innovation, the University of Oxford’s technology transfer company.
The study was carried out with funding from the Clarendon Fund at Oxford.

quinta-feira, 1 de março de 2012

UNITAR: Nanotechnology and Manufactured Nanomaterials



Overview
Nanotechnology/Manufactured Nanomaterials is an exciting new field that promises a broad array of benefits to humans and our environment. However, with these clear benefits come potential risks to the environment and human health - risks that, to-date, are not fully known.

UNITAR is embarking with our partner OECD, within the framework of the IOMC to raise awareness in countries about this new topic - including what the implications for developing and transition countries will be as nano-based or nano-containing products are traded across borders, into jurisdictions where there is little or no capacity to address them.
Activities commenced in late 2009 with a first round of global regional awareness-raising workshops for all UN developing and transition countries. These workshops, the first of which was held in Beijing for Asia-Pacific countries, briefed participants about nanotechnology and manufactured nanomaterials, their potential benefits and risks, and possible implications for governments and other stakeholders.

These awareness-raising workshops were then followed by a second round of regional workshops in early 2011, requested by countries, as a follow-up to the first round. For the full list of regional workshops, please click here.
This work takes its mandate from Resolution II/4 of the Second International Conference on Chemicals Management (ICCM-2), which was held in Geneva in May, 2009. The resolution was adopted by all governments and stakeholders present. The resolution comprises (in part) the following language: “[ICCM-2]…encourages Governments and other stakeholders to assist developing countries and countries with economies in transition to enhance their capacity to use and manage nanotechnologies and manufactured nanomaterials responsibly, to maximize potential benefits and to minimize potential risks” (see ICCM-2 report, SAICM/ICCM.2/15, advance copy of 27 May 2009).
Further to the decision of ICCM-2, the June 2009 Joint Meeting of the OECD instructed UNITAR, in cooperation with the OECD Secretariat, to undertake awareness raising and other related activities in developing countries regarding the potential risks (e.g. to the environment or human health) and benefits (e.g. decreased costs of low-maintenance products, or use in environmental remediation) of nanotechnology and nanomaterials.

As a result, a 2010 UNITAR survey was conducted in OECD and non-OECD countries to identify information pertaining to legislation, national governance, and experiences in awareness-raising in regard to nanotechnology and manufactured nanomaterials. To view a summary of the results of the survey, please click here.
In addition to the series of awareness-raising workshops and survey, UNITAR, with the support of the Government of Switzerland, will also undertake pilot projects to assist developing and transition countries to develop programmatic capacities to address nano issues at the national level. For more information, please click here.
_________________________________________

Nanotechnology and Manufactured Nanomaterials

Pilot Projects

Starting in 2011, UNITAR will assist three countries in undertaking pilot projects aimed to develop and/or strengthen capacities to address Nanotechnology and Manufactured Nanomaterials.
These projects, which are provided with funding support from the Swiss Agency for Development and Cooperation (SDC), will generate experiences and lessons learned that will be transmitted for deliberation at the third International Conference on Chemicals Management (ICCM-3), to be held in 2012.
UNITAR will develop guidance and training materials to ensure that participating countries are aware of the current state of the field, and some of the possible actions that can take place at the national level.

To initiate the development of guidance, a draft outline of a "Nano National Profile" chapter has been developed for comment at the regional workshops.
Regions: