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segunda-feira, 19 de março de 2012

Researchers examine toxic effects of titanium nanoparticles in human cells, mice

Scientists have concluded that titanium oxide nanoparticles can cause dysfunction in human cells from the lining of the umbilical vein, in a study demonstrating that the nanomaterial inhibits cell proliferation and causes inflammation leading to increased cell death and oxidative stress. 
The research, by scientists from the Mexican Institute of Cardiology, is published in Chemical Research in Toxicology.
A second in vivo study examining the genotoxicity of titanium oxide anatase nanoparticles to male mice has reported that the nanomaterial is not genotoxic when assessed with two genetic mutation tests.
However the researchers from the US Food and Drug Administration (FDA) found that the nanoparticles can reach the mouse bone marrow and are capable of inducing cytotoxicity in this tissue. 
The study is published in the journal Mutation Research/Genetic Toxicology and Environmental Mutagenesis.