Good news indeed for NanoSight users; publication of this ASTM Standard is a milestone in the growth and acceptance of NTA, allowing for unambiguous understanding of the technique and how it presents data.
Multiple users have requested this basic definition of the technique as they present data to regulatory bodies, as more of our data is being used in product approvals and clinical trials. In addition, papers don’t necessarily need to fully explain how the system works in order to present data derived from the technique as reference to this guide is sufficient explanation of how they obtained their numbers.
The publication is American Society of Testing Materials ASTM E2834 - Standard Guide for Measurement of Particle Size Distribution of Nanomaterials in Suspension by Nanoparticle Tracking Analysis (NTA). It details application of Nanoparticle Tracking Analysis to measurement of particle size distributions for suspended particles from ~10nm to the onset of sedimentation. It provides a rigorous review of the core science driving Brownian motion and the derived parameters of mean, mode, percentile values and concentration.
We thank Duncan Griffiths, NanoSight’s USA West Sales Manager, who has championed ASTM E2834 through three years of scientific committee appraisals. Duncan comments “The scrutiny of some demanding third-party experts has been fundamental in producing this document. The result is a meticulous presentation of science and methodology with which we are very pleased. Whilst this Standard is clearly a milestone, it is also a foundation for more. We will move to provide industry with test methods for specific materials then lock in the technique and allow formalization of some of the measurement methods. This will also prove useful for new users who are looking for SOP’s from us, as well as for regulatory authorities seeking standardization in use of NTA”.
The timing of this publication is helpful, as the European Commission move to consider methodologies to address the characterization challenges of their recently-published definition of Nanomaterials. Here we see a significant role for NTA’s unique nanoparticle counting capability. Click here for this EU publication.